The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy

L Shen, X Sun, Z Fu, G Yang, J Li, L Yao - Clinical Cancer Research, 2012 - AACR
L Shen, X Sun, Z Fu, G Yang, J Li, L Yao
Clinical Cancer Research, 2012AACR
It is well established that the altered metabolism exhibited by cancer cells, including high
rates of glycolysis, lactate production, and biosynthesis of lipids, nucleotides, and other
macromolecules, and which may occur either as a consequence or as a cause of
tumorigenesis, plays an essential role in cancer progression. Recently, the tumor
suppressor p53 was found to play a central role in this process. Here, we review the role of
p53 in modulating tumor metabolism. Specifically, we focus on the functions of p53 in …
Abstract
It is well established that the altered metabolism exhibited by cancer cells, including high rates of glycolysis, lactate production, and biosynthesis of lipids, nucleotides, and other macromolecules, and which may occur either as a consequence or as a cause of tumorigenesis, plays an essential role in cancer progression. Recently, the tumor suppressor p53 was found to play a central role in this process. Here, we review the role of p53 in modulating tumor metabolism. Specifically, we focus on the functions of p53 in regulating aerobic glycolysis, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis and oxidation, and glutamine metabolism, and we discuss the therapeutic strategy whereby p53 helps to prevent malignant progression. Clin Cancer Res; 18(6); 1561–7. ©2012 AACR.
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