Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

SJ King, AM Isaacs, E O'Farrell, A Abizaid - Hormones and behavior, 2011 - Elsevier
Ghrelin is an orexigenic peptide that acts within the central nervous system to stimulate
appetite and food intake via the growth hormone secretagogue receptor (GHS-R). It has
been hypothesized that ghrelin modulates food intake in part by stimulating reward
pathways in the brain and potentially stimulating the intake of palatable foods. Here we
examined the effects of chronic ghrelin administration in the ventral tegmental area (VTA) via
osmotic minipumps on 1) ad libitum food intake and bodyweight; 2) macronutrient …