[HTML][HTML] Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure

Z Yin, J Ren, W Guo - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Z Yin, J Ren, W Guo
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2015Elsevier
Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression,
distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of
sarcomeric proteins have been implicated to play a role in the onset and development of
human heart failure. In this mini-review, we summarized isoform transitions of several most
widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin
and myosin binding protein-C, and the consequence of these abnormal isoform transitions …
Abstract
Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression, distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of sarcomeric proteins have been implicated to play a role in the onset and development of human heart failure. In this mini-review, we summarized isoform transitions of several most widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin and myosin binding protein-C, and the consequence of these abnormal isoform transitions. Even though the isoform transitions of sarcomeric proteins have been described in individual sarcomeric protein reviews, no concise summary of these results has been presented previously. This review is intended to fill this gap and discuss possible future perspectives.
Elsevier