The human Mediator complex: a versatile, genome-wide regulator of transcription

DJ Taatjes - Trends in biochemical sciences, 2010 - cell.com
Trends in biochemical sciences, 2010cell.com
The Mediator complex interacts extensively with the RNA polymerase II enzyme and
regulates its ability to express protein-coding genes. The mechanisms by which Mediator
regulates gene expression remain poorly understood, in part because the structure of
Mediator and even its composition can change, depending upon the promoter context.
Combined with the sheer size of the human Mediator complex (26 subunits, 1.2 MDa), this
structural adaptability bestows seemingly unlimited regulatory potential within the complex …
The Mediator complex interacts extensively with the RNA polymerase II enzyme and regulates its ability to express protein-coding genes. The mechanisms by which Mediator regulates gene expression remain poorly understood, in part because the structure of Mediator and even its composition can change, depending upon the promoter context. Combined with the sheer size of the human Mediator complex (26 subunits, 1.2 MDa), this structural adaptability bestows seemingly unlimited regulatory potential within the complex. Recent efforts to understand Mediator structure and function have identified expanded roles that include control of both pre- and post-initiation events; it is also evident that Mediator performs both general and gene-specific roles to regulate gene expression.
cell.com