[HTML][HTML] Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-β-induced apoptosis in hepatoma cells
KY Kim, BC Kim, Z Xu, SJ Kim - Journal of Biological Chemistry, 2004 - ASBMB
Although transforming growth factor β1 (TGF-β1) acts via the Smad signaling pathway to
initiate de novo gene transcription, the TGF-β1-induced MAPK kinase activation that is
involved in the regulation of apoptosis is less well understood. Even though the p38 MAP
kinase and c-Jun NH 2-terminal kinases (JNKs) are involved in TGF-β1-induced cell death
in hepatoma cells, the upstream mediators of these kinases remain to be defined. We show
here that the members of the mixed lineage kinase (MLK) family (including MLK1, MLK2 …
initiate de novo gene transcription, the TGF-β1-induced MAPK kinase activation that is
involved in the regulation of apoptosis is less well understood. Even though the p38 MAP
kinase and c-Jun NH 2-terminal kinases (JNKs) are involved in TGF-β1-induced cell death
in hepatoma cells, the upstream mediators of these kinases remain to be defined. We show
here that the members of the mixed lineage kinase (MLK) family (including MLK1, MLK2 …