Osteoclast ultrastructure in Paget's disease
A Rebel, K Malkani, M Basle, CH Bregeon - Calcified tissue research, 1976 - Springer
A Rebel, K Malkani, M Basle, CH Bregeon
Calcified tissue research, 1976•SpringerThe ultrastructural study of osteoclasts in biopsies from 12 patients with Paget's disease
reveals several cytological anomalies. In particular, nuclear inclusions, consisting
essentially of striated filaments about 150 Å in diameter, often organized in bundles and
sometimes in paracrystalline arrays, appear to be specific to the disease. Morphologically,
the inclusions are remarkably similar to those observed in various cases of viral attack, and
the hypothesis of the action of a possible external agent in Paget's disease cannot be ruled …
reveals several cytological anomalies. In particular, nuclear inclusions, consisting
essentially of striated filaments about 150 Å in diameter, often organized in bundles and
sometimes in paracrystalline arrays, appear to be specific to the disease. Morphologically,
the inclusions are remarkably similar to those observed in various cases of viral attack, and
the hypothesis of the action of a possible external agent in Paget's disease cannot be ruled …
Abstract
The ultrastructural study of osteoclasts in biopsies from 12 patients with Paget’s disease reveals several cytological anomalies. In particular, nuclear inclusions, consisting essentially of striated filaments about 150 Å in diameter, often organized in bundles and sometimes in paracrystalline arrays, appear to be specific to the disease. Morphologically, the inclusions are remarkably similar to those observed in various cases of viral attack, and the hypothesis of the action of a possible external agent in Paget’s disease cannot be ruled out.
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