[HTML][HTML] Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids [S]
M Sharma, A Von Zychlinski-Kleffmann… - Journal of lipid …, 2015 - ASBMB
Elevated levels of lipoprotein (a)[Lp (a)] are a well-established risk factor for developing
CVD. While Lp (a) levels are thought to be independent of other plasma lipoproteins, some
trials have reported a positive association between Lp (a) and HDL. Whether Lp (a) has a
direct effect on HDL is not known. Here we investigated to determine whether Lp (a) had any
effect on the ABCA1 pathway of HDL production in liver cells. Incubation of HepG2 cells with
Lp (a) upregulated the PPARγ protein by 1.7-fold and the liver X receptor α protein by 3-fold …
CVD. While Lp (a) levels are thought to be independent of other plasma lipoproteins, some
trials have reported a positive association between Lp (a) and HDL. Whether Lp (a) has a
direct effect on HDL is not known. Here we investigated to determine whether Lp (a) had any
effect on the ABCA1 pathway of HDL production in liver cells. Incubation of HepG2 cells with
Lp (a) upregulated the PPARγ protein by 1.7-fold and the liver X receptor α protein by 3-fold …