[HTML][HTML] Crystal structure of the native plasminogen reveals an activation‐resistant compact conformation
Y Xue, C Bodin, K Olsson - Journal of Thrombosis and Haemostasis, 2012 - Elsevier
Background: Plasminogen is the zymogen form of plasmin and the precursor of angiostatin.
It has been implicated in a variety of disease states, including thrombosis, bleeding and
cancers. The native plasminogen, known as Glu‐plasminogen, contains seven domains
comprising the N‐terminal peptide domain (NTP), five kringle domains (K1–K5) and the C‐
terminal serine protease domain (SP). Previous studies have established that the lysine
binding site (LBS) of the conserved kringle domains plays a crucial role in mediating the …
It has been implicated in a variety of disease states, including thrombosis, bleeding and
cancers. The native plasminogen, known as Glu‐plasminogen, contains seven domains
comprising the N‐terminal peptide domain (NTP), five kringle domains (K1–K5) and the C‐
terminal serine protease domain (SP). Previous studies have established that the lysine
binding site (LBS) of the conserved kringle domains plays a crucial role in mediating the …