[PDF][PDF] Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score …

J Cuzick, M Dowsett, S Pineda, C Wale, J Salter… - J Clin Oncol, 2011 - stratifyer.de
J Cuzick, M Dowsett, S Pineda, C Wale, J Salter, E Quinn, L Zabaglo, E Mallon, AR Green…
J Clin Oncol, 2011stratifyer.de
Purpose We recently reported that the mRNA-based, 21-gene Genomic Health recurrence
score (GHI-RS) provided additional prognostic information regarding distant recurrence
beyond that obtained from classical clinicopathologic factors (age, nodal status, tumor size,
grade, endocrine treatment) in women with early breast cancer, confirming earlier reports.
The aim of this article is to determine how much of this information is contained in standard
immunohistochemical (IHC) markers.
Purpose
We recently reported that the mRNA-based, 21-gene Genomic Health recurrence score (GHI-RS) provided additional prognostic information regarding distant recurrence beyond that obtained from classical clinicopathologic factors (age, nodal status, tumor size, grade, endocrine treatment) in women with early breast cancer, confirming earlier reports. The aim of this article is to determine how much of this information is contained in standard immunohistochemical (IHC) markers.
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