[HTML][HTML] Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells
X Jiao, PC Billings, MP O'Connell, FS Kaplan… - Journal of Biological …, 2007 - ASBMB
Cell surface heparan sulfate proteoglycans (HSPGs) have been implicated in bone
morphogenetic protein (BMP)-mediated morphogenesis by regulating BMP activity and
gradient formation. However, the direct role of HSPGs in BMP signaling is poorly
understood. Here we show that HSPGs directly regulate BMP2-mediated transdifferentiation
of C2C12 myoblasts into osteoblasts. HSPGs sequester BMP2 at the cell surface and
mediate BMP2 internalization. Depletion of cell surface HSPGs by heparinase III treatment …
morphogenetic protein (BMP)-mediated morphogenesis by regulating BMP activity and
gradient formation. However, the direct role of HSPGs in BMP signaling is poorly
understood. Here we show that HSPGs directly regulate BMP2-mediated transdifferentiation
of C2C12 myoblasts into osteoblasts. HSPGs sequester BMP2 at the cell surface and
mediate BMP2 internalization. Depletion of cell surface HSPGs by heparinase III treatment …