A mouse model of retinal ischemia-reperfusion injury through elevation of intraocular pressure
MJ Hartsock, H Cho, L Wu, WJ Chen, J Gong… - JoVE (Journal of …, 2016 - jove.com
Retinal ischemia-reperfusion (I/R) is a pathophysiological process contributing to cellular
damage in multiple ocular conditions, including glaucoma, diabetic retinopathy, and retinal
vascular occlusions. Rodent models of I/R injury are providing significant insights into
mechanisms and treatment strategies for human I/R injury, especially with regard to
neurodegenerative damage in the retinal neurovascular unit. Presented here is a protocol
for inducing retinal I/R injury in mice through elevation of intraocular pressure (IOP). In this …
damage in multiple ocular conditions, including glaucoma, diabetic retinopathy, and retinal
vascular occlusions. Rodent models of I/R injury are providing significant insights into
mechanisms and treatment strategies for human I/R injury, especially with regard to
neurodegenerative damage in the retinal neurovascular unit. Presented here is a protocol
for inducing retinal I/R injury in mice through elevation of intraocular pressure (IOP). In this …