The neurovascular unit and the pathophysiologic basis of diabetic retinopathy
TW Gardner, JR Davila - Graefe's Archive for Clinical and Experimental …, 2017 - Springer
Graefe's Archive for Clinical and Experimental Ophthalmology, 2017•Springer
Purpose To relate the concept of the retinal neurovascular unit and its alterations in diabetes
to the pathophysiology of diabetic retinopathy. Methods Case illustrations and conceptual
frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the
retinal neurovascular unit with the progression of diabetes. Results Retinopathy treatment
should address pathophysiologic processes rather than pathologic lesions as is current
practice. Conclusions Future improvements in the treatment of diabetic retinopathy requires …
to the pathophysiology of diabetic retinopathy. Methods Case illustrations and conceptual
frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the
retinal neurovascular unit with the progression of diabetes. Results Retinopathy treatment
should address pathophysiologic processes rather than pathologic lesions as is current
practice. Conclusions Future improvements in the treatment of diabetic retinopathy requires …
Purpose
To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
Methods
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.
Results
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
Conclusions
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.
Springer