Beyond hemoglobin A1c—need for additional markers of risk for diabetic microvascular complications
IB Hirsch, M Brownlee - Jama, 2010 - jamanetwork.com
IN 1993, THE DIABETES CONTROL AND COMPLICATIONS Trial1 demonstrated that
intensive therapy lowered time-averaged blood glucose values (measured as hemoglobin
A1C [HbA1C]) and significantly reduced development of microvascular complications in type
1 diabetes. For example, intensive therapy reduced the risk of sustained retinopathy
progression by 73% compared with standard treatment. Such significant reductions led to
the recommendation by professional societies that for microvascular disease prevention, the …
intensive therapy lowered time-averaged blood glucose values (measured as hemoglobin
A1C [HbA1C]) and significantly reduced development of microvascular complications in type
1 diabetes. For example, intensive therapy reduced the risk of sustained retinopathy
progression by 73% compared with standard treatment. Such significant reductions led to
the recommendation by professional societies that for microvascular disease prevention, the …