Identification of fibronectin binding sites in dermatopontin and their biological function
A Kato, O Okamoto, W Wu, N Matsuo, J Kumai… - Journal of …, 2014 - Elsevier
Background Dermatopontin (DP) is a 22 kDa acidic extracellular matrix (ECM) protein that
plays a critical role in both ECM structure and wound healing. Previously, we demonstrated
that DP interacts with fibronectin (Fn) and promotes formation of insoluble Fn fibrils that are
called activated Fn (Kato et al., J Biol Chem 2011; 286: 14861–9). Objective Details of the
interaction between DP and Fn are investigated to further examine the biological functions of
DP. Methods Interactive sites between Fn and DP were examined by a solid-phase assay …
plays a critical role in both ECM structure and wound healing. Previously, we demonstrated
that DP interacts with fibronectin (Fn) and promotes formation of insoluble Fn fibrils that are
called activated Fn (Kato et al., J Biol Chem 2011; 286: 14861–9). Objective Details of the
interaction between DP and Fn are investigated to further examine the biological functions of
DP. Methods Interactive sites between Fn and DP were examined by a solid-phase assay …