[HTML][HTML] Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
The cholinergic anti-inflammatory pathway is an efferent vagus nerve–based mechanism
that regulates immune responses and cytokine production through α7 nicotinic acetylcholine
receptor (α7nAChR) signaling. Decreased efferent vagus nerve activity is observed in
inflammatory bowel disease. We determined whether central activation of this pathway alters
inflammation in mice with colitis and the mediating role of a vagus nerve-to-spleen circuit
and α7nAChR signaling. Two experimental models of colitis were used in C57BL/6 mice …
that regulates immune responses and cytokine production through α7 nicotinic acetylcholine
receptor (α7nAChR) signaling. Decreased efferent vagus nerve activity is observed in
inflammatory bowel disease. We determined whether central activation of this pathway alters
inflammation in mice with colitis and the mediating role of a vagus nerve-to-spleen circuit
and α7nAChR signaling. Two experimental models of colitis were used in C57BL/6 mice …