[HTML][HTML] Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver
disease and is now considered to be the hepatic manifestation of the metabolic syndrome.
However, the role of steatosis per se and the precise factors required in the progression to
steatohepatitis or insulin resistance remain elusive. The JAK-STAT pathway is critical in
mediating signaling of a wide variety of cytokines and growth factors. Mice with hepatocyte-
specific deletion of Janus kinase 2 (L-JAK2 KO mice) develop spontaneous steatosis as …
disease and is now considered to be the hepatic manifestation of the metabolic syndrome.
However, the role of steatosis per se and the precise factors required in the progression to
steatohepatitis or insulin resistance remain elusive. The JAK-STAT pathway is critical in
mediating signaling of a wide variety of cytokines and growth factors. Mice with hepatocyte-
specific deletion of Janus kinase 2 (L-JAK2 KO mice) develop spontaneous steatosis as …