JANUS under stress—role of JAK/STAT signaling pathway in vascular diseases
K Grote, M Luchtefeld, B Schieffer - Vascular pharmacology, 2005 - Elsevier
They were more than just another kinases (JAK), when they were first described in the late
80s and named JAK kinases. The mandatory role of this novel family of dual active janus
kinases (JAK) and their substrates the signal transducers and activators of transcription
(STAT) was demonstrated in mice who died during embryogenesis when lacking a
functional allele, eg that of JAK2. Initially, the JAK/STAT signaling pathway was discovered
as the primary mediator of intracellular signaling induced by interferon in hematopoietic and …
80s and named JAK kinases. The mandatory role of this novel family of dual active janus
kinases (JAK) and their substrates the signal transducers and activators of transcription
(STAT) was demonstrated in mice who died during embryogenesis when lacking a
functional allele, eg that of JAK2. Initially, the JAK/STAT signaling pathway was discovered
as the primary mediator of intracellular signaling induced by interferon in hematopoietic and …
