Four-and-a-half LIM domains protein 2 is a coactivator of Wnt signaling in diabetic kidney disease
SY Li, PH Huang, DC Tarng, TP Lin… - Journal of the …, 2015 - journals.lww.com
Diabetic kidney disease (DKD) is a microvascular complication that leads to kidney
dysfunction and ESRD, but the underlying mechanisms remain unclear. Podocyte Wnt-
pathway activation has been demonstrated to be a trigger mechanism for various proteinuric
diseases. Notably, four-and-a-half LIM domains protein 2 (FHL2) is highly expressed in
urogenital systems and has been implicated in Wnt/β-catenin signaling. Here, we used in
vitro podocyte culture experiments and a streptozotocin-induced DKD model in FHL2 gene …
dysfunction and ESRD, but the underlying mechanisms remain unclear. Podocyte Wnt-
pathway activation has been demonstrated to be a trigger mechanism for various proteinuric
diseases. Notably, four-and-a-half LIM domains protein 2 (FHL2) is highly expressed in
urogenital systems and has been implicated in Wnt/β-catenin signaling. Here, we used in
vitro podocyte culture experiments and a streptozotocin-induced DKD model in FHL2 gene …