[HTML][HTML] Association between Interlukin-6 (IL-6), Interlukin-10 (IL-10) and depression in patients undergoing Hematopoietic stem cell transplantation
M Tavakoli-Ardakani, M Mehrpooya… - … -Oncology and Stem …, 2015 - ncbi.nlm.nih.gov
International Journal of Hematology-Oncology and Stem Cell Research, 2015•ncbi.nlm.nih.gov
Background: The release of pro-inflammatory cytokines is responsible for the variety of
behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this
study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing
hematopoietic stem cell transplantation (HSCT). Materials and Methods: 66 patients in this
cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were
assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum …
behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this
study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing
hematopoietic stem cell transplantation (HSCT). Materials and Methods: 66 patients in this
cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were
assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum …
Abstract
Background: The release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing hematopoietic stem cell transplantation (HSCT).
Materials and Methods: 66 patients in this cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum interleukin (IL)-6,(IL)-10 and high sensitive C-reactive protein (hs-CRP) were assessed on the same time. Association between these biomarkers with depression was evaluated using SPSS version 20.
Results: A total of 66 patients with the mean age of 41.18+ 13.92 and 41.95+ 12.35 years old in non depressed and depressed group respectively were enrolled in this study. Patients with depression showed significantly higher levels of serum IL-6 and the IL-6-to-IL-10 ratio compared to patients without depression (p< 0.001). There was no statistically significant association between IL-10 and hs-CRP with depression in this group of the patients.
Conclusions: High IL-6 level has significant association with depression in patients undergoing HSCT. In conclusion, since IL-6 can affect the outcomes after HSCT and depression was associated with increased serum IL-6 level, early identification of depression can be beneficial in these patients.
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