People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of
developing renal diseases. However, the mechanisms underlying APOL1-associated renal
diseases are unknown. Because the APOL1 gene is unique to humans and some primates,
new animal models are needed to understand the function of APOL1 in vivo. We generated
transgenic Drosophila fly lines expressing the human APOL1 wild type allele (G0) or the
predominant APOL1 risk allele (G1) in different tissues. Ubiquitous expression of APOL1 G0 …