[HTML][HTML] Apobec-1 complementation factor modulates liver regeneration by post-transcriptional regulation of interleukin-6 mRNA stability
V Blanc, KJ Sessa, S Kennedy, J Luo… - Journal of biological …, 2010 - ASBMB
Apobec-1 complementation factor (ACF) is the RNA binding subunit of a core complex that
mediates C to U RNA editing of apolipoprotein B (apoB) mRNA. Targeted deletion of the
murine Acf gene is early embryonic lethal and Acf−/− blastocysts fail to implant and
proliferate, suggesting that ACF plays a key role in cell growth and differentiation. Here we
demonstrate that heterozygous Acf+/− mice exhibit decreased proliferation and impaired
liver mass restitution following partial hepatectomy (PH). To pursue the mechanism of …
mediates C to U RNA editing of apolipoprotein B (apoB) mRNA. Targeted deletion of the
murine Acf gene is early embryonic lethal and Acf−/− blastocysts fail to implant and
proliferate, suggesting that ACF plays a key role in cell growth and differentiation. Here we
demonstrate that heterozygous Acf+/− mice exhibit decreased proliferation and impaired
liver mass restitution following partial hepatectomy (PH). To pursue the mechanism of …
