[HTML][HTML] The Villin1 gene promoter drives Cre recombinase expression in extraintestinal tissues
M Rutlin, D Rastelli, WT Kuo, JA Estep… - Cellular and …, 2020 - cmghjournal.org
Villin, encoded by Vil1, is an actinbinding protein expressed by intestinal, hepatobiliary, and
renal tubular epithelial cells. 1 Transgenic mice in which the Vil1 promoter drives Cre
recombinase expression are widely used to inactivate genes in the intestinal epithelium. The
4 most commonly used Vil1Cre lines were generated by independent groups using distinct
promoter constructs. 2, 3 Although these lines have been well-characterized in the intestine,
their extraintestinal Cre activity has not been fully defined or compared. We first studied the …
renal tubular epithelial cells. 1 Transgenic mice in which the Vil1 promoter drives Cre
recombinase expression are widely used to inactivate genes in the intestinal epithelium. The
4 most commonly used Vil1Cre lines were generated by independent groups using distinct
promoter constructs. 2, 3 Although these lines have been well-characterized in the intestine,
their extraintestinal Cre activity has not been fully defined or compared. We first studied the …
