Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo
PC Rensen, N Herijgers, MH Netscher… - Journal of lipid …, 1997 - ASBMB
Apolipoprotein E (apoE) is an important determinant for the uptake of triglyceride-rich
emulsions and lipoproteins by the liver, and exerts affinity for both the LDL receptor (LDLr)
and a distinct liver-specific recognition site. Our current aim was to assess the mechanism
underlying the receptor-specificity of apoE-carrying lipoproteins. Triglyceride-rich emulsions
were synthesized, with mean sizes of 50, 80, and 150 nm. These fractions efficiently
acquired apoE from rat serum, and were processed by LPL in vivo with a similar efficiency …
emulsions and lipoproteins by the liver, and exerts affinity for both the LDL receptor (LDLr)
and a distinct liver-specific recognition site. Our current aim was to assess the mechanism
underlying the receptor-specificity of apoE-carrying lipoproteins. Triglyceride-rich emulsions
were synthesized, with mean sizes of 50, 80, and 150 nm. These fractions efficiently
acquired apoE from rat serum, and were processed by LPL in vivo with a similar efficiency …
