Tolerance induction by means of costimulation blockade has been successfully applied in
solid organ transplantation; however, its efficacy in vascularized composite
allotransplantation, containing a vascularized bone marrow component and thus a constant
source of donor‐derived stem cells, remains poorly explored. In this study,
osteomyocutaneous allografts (alloOMCs) from Balb/c (H2 d) mice were transplanted into
C57BL/6 (H2 b) recipients. Immunosuppression consisted of 1 mg anti‐CD154 on day 0, 0.5 …