[HTML][HTML] Nonionic detergents induce dimerization among members of the Bcl-2 family
YT Hsu, RJ Youle - Journal of Biological Chemistry, 1997 - ASBMB
Members of the Bcl-2 family (including Bcl-2, Bcl-X L, and Bax) play key roles in the
regulation of apoptosis. These proteins are believed to be membrane-associated and have
been proposed to regulate apoptosis through both homodimerization and
heterodimerization. We have found that whereas Bcl-2 is predominantly membrane-
associated as previously reported, significant amounts of Bcl-X L and most of the Bax
proteins are not membrane-associated and thus appear in the cytosolic fraction of thymocyte …
regulation of apoptosis. These proteins are believed to be membrane-associated and have
been proposed to regulate apoptosis through both homodimerization and
heterodimerization. We have found that whereas Bcl-2 is predominantly membrane-
associated as previously reported, significant amounts of Bcl-X L and most of the Bax
proteins are not membrane-associated and thus appear in the cytosolic fraction of thymocyte …