Dexamethasone suppresses the Th17/1 cell polarization in the CD4+ T cells from patients with primary immune thrombocytopenia
J Li, M Hua, X Hu, Y Zhang, Q Feng, J Qiu, L Shao… - Thrombosis …, 2020 - Elsevier
Introduction Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease
with increased Th17 cells in peripheral blood. Th17/1 cells, which were recently
characterized as a new differentiated Th17 lineage secreting IL-17 and IFN-γ, play an
important role in the pathogenesis of multiple autoimmune diseases. In this study, we
investigated whether Th17/1 cells are involved in the pathogenesis of ITP. Materials and
methods Peripheral blood was obtained from 44 ITP patients and 50 healthy controls. The …
with increased Th17 cells in peripheral blood. Th17/1 cells, which were recently
characterized as a new differentiated Th17 lineage secreting IL-17 and IFN-γ, play an
important role in the pathogenesis of multiple autoimmune diseases. In this study, we
investigated whether Th17/1 cells are involved in the pathogenesis of ITP. Materials and
methods Peripheral blood was obtained from 44 ITP patients and 50 healthy controls. The …
