[HTML][HTML] Gly-Pro-Arg confers stability similar to Gly-Pro-Hyp in the collagen triple-helix of host-guest peptides
W Yang, VC Chan, A Kirkpatrick, JAM Ramshaw… - Journal of Biological …, 1997 - ASBMB
A set of host-guest peptides of the form Ac (Gly-Pro-Hyp) 3-Gly-XY-(Gly-Pro-Hyp) 4-Gly-Gly-
NH 2 has been designed to evaluate the propensity of different Gly-XY triplets for the triple-
helix conformation (Shah, NK, Ramshaw, JAM, Kirkpatrick, A., Shah, C., and Brodsky,
B.(1996) Biochemistry 35, 10262–10268). All Gly-XY guest triplets led to a decrease in
melting temperature from the host (Gly-Pro-Hyp) 8 peptide except for Gly-Pro-Arg. In this Gly-
Pro-Hyp-rich environment, Gly-Pro-Arg was found to be as stabilizing as Gly-Pro-Hyp …
NH 2 has been designed to evaluate the propensity of different Gly-XY triplets for the triple-
helix conformation (Shah, NK, Ramshaw, JAM, Kirkpatrick, A., Shah, C., and Brodsky,
B.(1996) Biochemistry 35, 10262–10268). All Gly-XY guest triplets led to a decrease in
melting temperature from the host (Gly-Pro-Hyp) 8 peptide except for Gly-Pro-Arg. In this Gly-
Pro-Hyp-rich environment, Gly-Pro-Arg was found to be as stabilizing as Gly-Pro-Hyp …