Exposure of red blood cells (RBCs) to catecholamines (epinephrine, phenylephrine, an agonist of α 1-adrenergic receptors, clonidine, an agonist of α 2-adrenergic receptors and isoproterenol, an agonist of β-adrenergic receptors) led to change in the RBC microrheological properties. When forskolin (10 μM), an AC stimulator was added to RBC suspension, the RBC deformability (RBCD) was increased by 17%(p< 0.05). Somewhat more significant deformability rise appeared after RBC incubation with dB-AMP (by 27%; p< 0.01). Red blood cell aggregation (RBCA) was significantly decreased under these conditions (p< 0.01). All drugs having PDE activity increased red cell deformability similarly. Some more changes of deformability was found after RBC incubation with pentoxifylline–25%(p< 0.05) and IBMX incubation was accompanied only by 15% rise of RBC deformability. The drugs with PDE inhibitory activity reduced red cell aggregation. The most significant RBCA reduction effect was found under cell incubation with pentoxifylline and inhibitor PDE 1–vinpocetine. On the whole RBCA reduction averaged 36%(p< 0.05) under RBCs incubation with PDE inhibitors. The rise of Ca 2+ influx, stimulated by A23187, was accompanied by an increase of RBCA, whereas red cell deformability was changed insignificantly. At the same time Ca 2+ entry blocking into the red cells by verapamil or its chelating in medium by EGTA led to significant RBCA decrease and deformability rise (p< 0.05).