Low-Affinity Hemoglobin Increases Tissue PO2and Decreases Arteriolar Diameter and Flow in the Rat Cremaster Muscle
MP Kunert, JF Liard, DJ Abraham, JH Lombard - Microvascular research, 1996 - Elsevier
The hypothesis that tissue oxygen delivery in excess of metabolic demand results in
vasoconstriction and reduced blood flow was tested in the cremaster muscle of anesthetized
Sprague–Dawley rats by studying the effects of an intravenous infusion of RSR-13, an
allosteric effector of hemoglobin. RSR-13 reduces the affinity of hemoglobin for oxygen,
causing a right shift in the oxygen dissociation curve. Thus, oxygen delivery to the tissues
was increased without elevations in blood flow or blood pressure. Tissue PO2, arteriolar …
vasoconstriction and reduced blood flow was tested in the cremaster muscle of anesthetized
Sprague–Dawley rats by studying the effects of an intravenous infusion of RSR-13, an
allosteric effector of hemoglobin. RSR-13 reduces the affinity of hemoglobin for oxygen,
causing a right shift in the oxygen dissociation curve. Thus, oxygen delivery to the tissues
was increased without elevations in blood flow or blood pressure. Tissue PO2, arteriolar …