Diversity of human U2AF splicing factors: Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest
The FEBS journal, 2006•Wiley Online Library
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of
two subunits, U2AF65 and U2AF35. During the past few years, a number of proteins related
to both U2AF65 and U2AF35 have been discovered. Here, we review the conserved
structural features that characterize the U2AF protein families and their evolutionary
emergence. We perform a comprehensive database search designed to identify U2AF
protein isoforms produced by alternative splicing, and we discuss the potential implications …
two subunits, U2AF65 and U2AF35. During the past few years, a number of proteins related
to both U2AF65 and U2AF35 have been discovered. Here, we review the conserved
structural features that characterize the U2AF protein families and their evolutionary
emergence. We perform a comprehensive database search designed to identify U2AF
protein isoforms produced by alternative splicing, and we discuss the potential implications …
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF65 and U2AF35. During the past few years, a number of proteins related to both U2AF65 and U2AF35 have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation.
Wiley Online Library