[HTML][HTML] Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic …
R Saito, H Abe, A Kunita, H Yamashita, Y Seto… - Modern Pathology, 2017 - Elsevier
Cancer cells use PD-L1 to evade antitumor immunity through interaction with programmed
cell death protein 1 (PD-1) on T cells. Recent whole-genome sequence studies revealed
frequent gene amplification of PD-L1 in Epstein–Barr virus-associated gastric cancer
(EBVaGC). To investigate the significance of PD-L1 in cancer cells and their
microenvironment in EBVaGC, we studied PD-L1 expression by analysis of the public
database and immunohistochemistry with fluorescent in situ hybridization (FISH) of the PD …
cell death protein 1 (PD-1) on T cells. Recent whole-genome sequence studies revealed
frequent gene amplification of PD-L1 in Epstein–Barr virus-associated gastric cancer
(EBVaGC). To investigate the significance of PD-L1 in cancer cells and their
microenvironment in EBVaGC, we studied PD-L1 expression by analysis of the public
database and immunohistochemistry with fluorescent in situ hybridization (FISH) of the PD …