[HTML][HTML] Celecoxib with neoadjuvant chemotherapy for breast cancer might worsen outcomes differentially by COX-2 expression and ER status: exploratory analysis of …
Journal of Clinical Oncology, 2019•ncbi.nlm.nih.gov
PURPOSE The overexpression of cyclooxygenase 2 (COX-2) gene, also known as
prostaglandin-endoperoxide synthase 2 (PTGS2), occurs in breast cancer, but whether it
affects response to anticox drugs remains unclear. We investigated the relationships
between PTGS2 expression, celecoxib use during neoadjuvant chemotherapy (NAC), and
both event-free survival (EFS) and overall survival (OS). MATERIALS AND METHODS We
analyzed a cohort of 156 patients with human epidermal growth factor receptor 2–negative …
prostaglandin-endoperoxide synthase 2 (PTGS2), occurs in breast cancer, but whether it
affects response to anticox drugs remains unclear. We investigated the relationships
between PTGS2 expression, celecoxib use during neoadjuvant chemotherapy (NAC), and
both event-free survival (EFS) and overall survival (OS). MATERIALS AND METHODS We
analyzed a cohort of 156 patients with human epidermal growth factor receptor 2–negative …
Abstract
PURPOSE
The overexpression of cyclooxygenase 2 (COX-2) gene, also known as prostaglandin-endoperoxide synthase 2 (PTGS2), occurs in breast cancer, but whether it affects response to anticox drugs remains unclear. We investigated the relationships between PTGS2 expression, celecoxib use during neoadjuvant chemotherapy (NAC), and both event-free survival (EFS) and overall survival (OS).
MATERIALS AND METHODS
We analyzed a cohort of 156 patients with human epidermal growth factor receptor 2–negative breast cancer from the REMAGUS02 (ISRCTN Registry No. 10059974) trial with pretreatment PTGS2 expression data. Patients were treated by sequential NAC (epirubicin plus cyclophosphamide followed by docetaxel with or without celecoxib). Experimental validation was performed on breast cancer cell lines. The Cancer and Leukemia Group B (CALGB) 30801 (ClinicalTrials. gov identifier:
ncbi.nlm.nih.gov
