[HTML][HTML] Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2
RE Temel, RG Lee, KL Kelley, MA Davis, R Shah… - Journal of lipid …, 2005 - ASBMB
The process of cholesterol absorption has yet to be completely defined at the molecular
level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons,
ACAT2 plays an important role in cholesterol absorption. However, it has been found that
cholesterol absorption is not completely inhibited in ACAT2-deficient (ACAT2 KO) mice.
Because ABCA1 mRNA expression was increased 3-fold in the small intestine of ACAT2 KO
mice, we hypothesized that ABCA1-dependent cholesterol efflux sustains cholesterol …
level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons,
ACAT2 plays an important role in cholesterol absorption. However, it has been found that
cholesterol absorption is not completely inhibited in ACAT2-deficient (ACAT2 KO) mice.
Because ABCA1 mRNA expression was increased 3-fold in the small intestine of ACAT2 KO
mice, we hypothesized that ABCA1-dependent cholesterol efflux sustains cholesterol …
