[HTML][HTML] Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and …
D Slijepcevic, RLPR Abbing, T Katafuchi, A Blank… - Hepatology, 2017 - journals.lww.com
The Na+‐taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal
for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a
subset of NTCP knockout mice and in mice treated with myrcludex B, a specific NTCP
inhibitor. Here, we elucidated which transport proteins mediate the hepatic uptake of
conjugated bile acids and demonstrated intestinal sensing of elevated bile acid levels in
plasma in mice. Mice or healthy volunteers were treated with myrcludex B. Hepatic bile acid …
for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a
subset of NTCP knockout mice and in mice treated with myrcludex B, a specific NTCP
inhibitor. Here, we elucidated which transport proteins mediate the hepatic uptake of
conjugated bile acids and demonstrated intestinal sensing of elevated bile acid levels in
plasma in mice. Mice or healthy volunteers were treated with myrcludex B. Hepatic bile acid …
