Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles
MN Sathe, K Woo, C Kresge, A Bugde… - Journal of Biological …, 2011 - ASBMB
ATP in bile is a potent secretogogue, stimulating biliary epithelial cell (BEC) secretion
through binding apical purinergic receptors. In response to mechanosensitive stimuli, BECs
release ATP into bile, although the cellular basis of ATP release is unknown. The aims of
this study in human and mouse BECs were to determine whether ATP release occurs via
exocytosis of ATP-enriched vesicles and to elucidate the potential role of the vesicular
nucleotide transporter SLC17A9 in purinergic signaling. Dynamic, multiscale, live cell …
through binding apical purinergic receptors. In response to mechanosensitive stimuli, BECs
release ATP into bile, although the cellular basis of ATP release is unknown. The aims of
this study in human and mouse BECs were to determine whether ATP release occurs via
exocytosis of ATP-enriched vesicles and to elucidate the potential role of the vesicular
nucleotide transporter SLC17A9 in purinergic signaling. Dynamic, multiscale, live cell …
