Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
P Fickert, MJ Pollheimer, D Silbert, T Moustafa… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: The quest for effective drugs to treat cholangiopathies led to the
development of norUDCA previously shown to have potent choleretic effects and to heal
cholangiopathy in Abcb4 knockout (Abcb4−/−) mice. Its mother compound UDCA had
detrimental effects in common bile duct ligated (CBDL) mice, presumably related to its
choleretic effects. norUDCA choleretic effects may therefore raise safety concerns when
used in cholangiopathies with biliary obstruction. We therefore aimed at comparing the …
development of norUDCA previously shown to have potent choleretic effects and to heal
cholangiopathy in Abcb4 knockout (Abcb4−/−) mice. Its mother compound UDCA had
detrimental effects in common bile duct ligated (CBDL) mice, presumably related to its
choleretic effects. norUDCA choleretic effects may therefore raise safety concerns when
used in cholangiopathies with biliary obstruction. We therefore aimed at comparing the …
