[PDF][PDF] Keloid lesions show increased IL-4/IL-13 signaling and respond to Th2-targeting dupilumab therapy
A Diaz, K Tan, H He, H Xu, I Cueto… - J Eur Acad Dermatol …, 2020 - researchgate.net
J Eur Acad Dermatol Venereol, 2020•researchgate.net
Keloids are benign growths representing a disrupted wound healing process involving
abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and
Asian populations, 2 and greatly impact quality of life. 3 Keloids show high recurrence rates
and current therapies (intralesional steroids, bleomycin, surgical excision, etc.) have limited
efficacy; 4 thus, presenting a high unmet need for better treatments. Genetic studies have
identified chromosome variants associated with keloid formation in AAs and Asians. 1, 5 A …
abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and
Asian populations, 2 and greatly impact quality of life. 3 Keloids show high recurrence rates
and current therapies (intralesional steroids, bleomycin, surgical excision, etc.) have limited
efficacy; 4 thus, presenting a high unmet need for better treatments. Genetic studies have
identified chromosome variants associated with keloid formation in AAs and Asians. 1, 5 A …
Keloids are benign growths representing a disrupted wound healing process involving abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and Asian populations, 2 and greatly impact quality of life. 3 Keloids show high recurrence rates and current therapies (intralesional steroids, bleomycin, surgical excision, etc.) have limited efficacy; 4 thus, presenting a high unmet need for better treatments. Genetic studies have identified chromosome variants associated with keloid formation in AAs and Asians. 1, 5 A genomic profiling study on lesional and non-lesional keloid skin from three AA patients
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