[HTML][HTML] Implication of interleukin-4 in wound healing
V Salmon-Ehr, L Ramont, G Godeau, P Birembaut… - Laboratory …, 2000 - Elsevier
Abstract Interleukin-4 (IL-4) is a pleiotropic cytokine that is able to activate connective tissue
cells and stimulate the accumulation of extracellular matrix macromolecules. In this report,
the expression of IL-4 in normal wound healing was studied by immunohistochemistry. The
effects of exogenous IL-4 or IL-4 antisense oligonucleotides administration were also
studied in mouse experimental wounds. IL-4 expression was detected in the lower dermis
below the wound as early as Day 1 after wounding. IL-4 expression was maximal by Day 4 …
cells and stimulate the accumulation of extracellular matrix macromolecules. In this report,
the expression of IL-4 in normal wound healing was studied by immunohistochemistry. The
effects of exogenous IL-4 or IL-4 antisense oligonucleotides administration were also
studied in mouse experimental wounds. IL-4 expression was detected in the lower dermis
below the wound as early as Day 1 after wounding. IL-4 expression was maximal by Day 4 …