Collectin-11 is a recently described soluble C-type lectin, a pattern recognition molecule of
the innate immune system that has distinct roles in host defense, embryonic development,
and acute inflammation. However, little is known regarding the role of collectin-11 in tissue
fibrosis. Here, we investigated collectin-11 in the context of renal ischemia-reperfusion
injury. Compared with wild-type littermate controls, Collec11 deficient (CL-11−/−) mice had
significantly reduced renal functional impairment, tubular injury, renal leukocyte infiltration …