Allosensitization following skin allografts in acute burn management: are burns patients suitable face transplant candidates?

TS Win, Q Frew, CJ Taylor, S Peacock… - Journal of Plastic …, 2015 - jprasurg.com
Composite tissue allotransplantation has become a recognized reconstructive option for
patients with extensive facial burns. Of 27 facial transplants carried out worldwide, 10 have
been performed for severe facial burns. Despite advances in transplant medicine, the
greatest barrier to both access to and success of transplantation remains sensitization to
human leucocyte antigens (HLAs). During the acute management of extensive burns,
deceased donor skin allografts without HLA-matching, are used as temporary dressings …