The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease
CM Magro, ME Dyrsen - Journal of the American Academy of Dermatology, 2008 - Elsevier
BACKGROUND: Direct immunofluorescent (DIF) testing defines an important diagnostic
adjunct in the classification of various inflammatory skin conditions; it requires fresh tissue, a
laboratory equipped to perform the procedure, and a pathologist skilled in its interpretation.
Although advances have been made in the development of antibodies that can be applied to
paraffin-embedded tissue, there has been no reported success on the application of paraffin
tissue–based immunohistochemistry as a potential substitute for DIF testing on skin biopsy …
adjunct in the classification of various inflammatory skin conditions; it requires fresh tissue, a
laboratory equipped to perform the procedure, and a pathologist skilled in its interpretation.
Although advances have been made in the development of antibodies that can be applied to
paraffin-embedded tissue, there has been no reported success on the application of paraffin
tissue–based immunohistochemistry as a potential substitute for DIF testing on skin biopsy …