Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages
SH Kim, CH Serezani, K Okunishi, Z Zaslona… - Journal of Biological …, 2011 - ASBMB
Toll-like receptors (TLRs) direct a proinflammatory program in macrophages. One mediator
whose generation is induced by TLR ligation is prostaglandin E 2 (PGE 2), which is well
known to increase intracellular cAMP upon G protein-coupled receptor ligation. How PGE
2/cAMP shapes the nascent TLR response and the mechanisms by which it acts remain
poorly understood. Here we explored PGE 2/cAMP regulation of NO production in primary
rat alveolar macrophages stimulated with the TLR4 ligand LPS. Endogenous PGE 2 …
whose generation is induced by TLR ligation is prostaglandin E 2 (PGE 2), which is well
known to increase intracellular cAMP upon G protein-coupled receptor ligation. How PGE
2/cAMP shapes the nascent TLR response and the mechanisms by which it acts remain
poorly understood. Here we explored PGE 2/cAMP regulation of NO production in primary
rat alveolar macrophages stimulated with the TLR4 ligand LPS. Endogenous PGE 2 …
