The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

LD Jager, R Dabelic, LW Waiboci, K Lau… - Journal of …, 2011 - Elsevier
Suppressors of cytokine signaling (SOCS) negatively regulate the immune response,
primarily by interfering with the JAK/STAT pathway. We have developed a small peptide
corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which
inhibits kinase activity by binding to the activation loop of tyrosine kinases such as JAK2 and
TYK2. Treatment of SJL/J mice with SOCS1-KIR beginning 12days post-immunization with
myelin basic protein (MBP) resulted in minimal symptoms of EAE, while most control treated …