The third international consensus definitions for sepsis and septic shock (Sepsis-3)

M Singer, CS Deutschman, CW Seymour… - Jama, 2016 - jamanetwork.com
Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function,
morphology, cell biology, biochemistry, immunology, and circulation), management, and
epidemiology of sepsis, suggesting the need for reexamination. Objective To evaluate and,
as needed, update definitions for sepsis and septic shock. Process A task force (n= 19) with
expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the …