[HTML][HTML] Perilipin 1 (Plin1) deficiency promotes inflammatory responses in lean adipose tissue through lipid dysregulation
Lipid droplets are specialized cellular organelles that contain neutral lipid metabolites and
play dynamic roles in energy homeostasis. Perilipin 1 (Plin1), one of the major lipid droplet-
binding proteins, is highly expressed in adipocytes. In mice, Plin1 deficiency impairs
peripheral insulin sensitivity, accompanied with reduced fat mass. However, the
mechanisms underlying insulin resistance in lean Plin1 knockout (Plin1−/−) mice are largely
unknown. The current study demonstrates that Plin1 deficiency promotes inflammatory …
play dynamic roles in energy homeostasis. Perilipin 1 (Plin1), one of the major lipid droplet-
binding proteins, is highly expressed in adipocytes. In mice, Plin1 deficiency impairs
peripheral insulin sensitivity, accompanied with reduced fat mass. However, the
mechanisms underlying insulin resistance in lean Plin1 knockout (Plin1−/−) mice are largely
unknown. The current study demonstrates that Plin1 deficiency promotes inflammatory …
