Tissue distribution, antigen specificity and effector functions of γδ T cells in human diseases

G De Libero - Springer seminars in immunopathology, 2000 - Springer
Springer seminars in immunopathology, 2000Springer
Conclusions In conclusion, the large number of studies on human γδ T cells have shown
that these lymphocytes share several characteristics in common with αβ T cells, and also
embody many unique properties. Some investigations have perhaps suffered a constant
analogy with the αβ T cell population, which has precluded new and original experimental
approaches. Nevertheless, this gigantic amount of work has provided solid clues for defining
the role of human γδ T cells in diseases. In addition, we have also learnt more about the …
Conclusions
In conclusion, the large number of studies on human γδ T cells have shown that these lymphocytes share several characteristics in common with αβ T cells, and also embody many unique properties. Some investigations have perhaps suffered a constant analogy with the αβ T cell population, which has precluded new and original experimental approaches. Nevertheless, this gigantic amount of work has provided solid clues for defining the role of human γδ T cells in diseases. In addition, we have also learnt more about the extreme plasticity of the immune system and its polymorphic capacity to adapt and recognize foreign molecules.
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