Activated human γδ T cells as stimulators of specific CD8+ T-cell responses to subdominant epstein barr virus epitopes: potential for immunotherapy of cancer
S Landmeier, B Altvater, S Pscherer… - Journal of …, 2009 - journals.lww.com
The efficacy of current cancer vaccines is limited by the functional heterogeneity and poor
availability and expansion of professional antigen-presenting cells (APCs). Besides their
potent innate effector properties, γδ T cells have been suggested to be involved in the
initiation and maintenance of adaptive immune responses. Here, we investigated the
capacity of human γδ T cells to induce expansion of virus-specific T cells to Epstein Barr
virus (EBV) antigens. Aminobisphosphonate-stimulated human peripheral blood-derived γδ …
availability and expansion of professional antigen-presenting cells (APCs). Besides their
potent innate effector properties, γδ T cells have been suggested to be involved in the
initiation and maintenance of adaptive immune responses. Here, we investigated the
capacity of human γδ T cells to induce expansion of virus-specific T cells to Epstein Barr
virus (EBV) antigens. Aminobisphosphonate-stimulated human peripheral blood-derived γδ …