Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse
KH Chan, R Zhang, JSC Kwan, VY Guo… - Journal of …, 2012 - Elsevier
BACKGROUND: Neuromyelitis optica (NMO) is a central nervous system inflammatory
demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4
autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and
relapse of NMO are uncertain. OBJECTIVE: Study the pathogenicity of AQP4 Ab in the
absence of complement activation. METHODS: Female C57BL/6N mice (human IgG cannot
activate mouse complements) pretreated with complete Freund's adjuvant (CFA, day 0) and …
demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4
autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and
relapse of NMO are uncertain. OBJECTIVE: Study the pathogenicity of AQP4 Ab in the
absence of complement activation. METHODS: Female C57BL/6N mice (human IgG cannot
activate mouse complements) pretreated with complete Freund's adjuvant (CFA, day 0) and …
