The expansion of circulating IL-6 and IL-17-secreting follicular helper T cells is associated with neurological disabilities in neuromyelitis optica spectrum disorders
C Monteiro, G Fernandes, TM Kasahara… - Journal of …, 2019 - Elsevier
Due to their function in assisting B cells, T FH cells may be involved in the production of
pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the
proportion of IL-6+ and IL-17+ T FH cell subsets was higher in NMOSD patients than healthy
individuals. The frequency of both T FH cell subsets were directly associated with disease
activity. By contrast, NMOSD patients with a higher proportion of IL-10+ T FH cell subsets
showed a lower neurological disabilities score. In summary, all findings suggest that …
pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the
proportion of IL-6+ and IL-17+ T FH cell subsets was higher in NMOSD patients than healthy
individuals. The frequency of both T FH cell subsets were directly associated with disease
activity. By contrast, NMOSD patients with a higher proportion of IL-10+ T FH cell subsets
showed a lower neurological disabilities score. In summary, all findings suggest that …
