Association of circulating follicular helper T cells with disease course of NMO spectrum disorders
YJ Li, F Zhang, Y Qi, GQ Chang, Y Fu, L Su… - Journal of …, 2015 - Elsevier
While follicular helper T (Tfh) cells have been shown to be involved in many autoimmune
diseases, the association of Tfh cells with the disease activity of neuromyelitis optica
spectrum disorders (NMOSDs) remains unclear. In this study, the CD4+ CXCR5+ PD-1+ Tfh
cell population in peripheral blood mononuclear cells (PBMCs) obtained from NMOSD
patients, age-and gender-matched healthy controls, and multiple sclerosis patients was
compared by flow cytometry. The serum levels of IL-21, IL-6, IL-17, TNF-α and IL-10 were …
diseases, the association of Tfh cells with the disease activity of neuromyelitis optica
spectrum disorders (NMOSDs) remains unclear. In this study, the CD4+ CXCR5+ PD-1+ Tfh
cell population in peripheral blood mononuclear cells (PBMCs) obtained from NMOSD
patients, age-and gender-matched healthy controls, and multiple sclerosis patients was
compared by flow cytometry. The serum levels of IL-21, IL-6, IL-17, TNF-α and IL-10 were …